The fire department evaluated about 40 patients and transported 25 people to hospitals, the department said in a news release.
Five people were in serious condition and 20 were in fair condition with minor injuries, the release said.
The wreck happened around 1 p.m. local time when a bus crashed through the center divider on the 405 Freeway in North Hills, reported CNN affiliate KABC, citing firefighters.
The cause of the crash has not been determined.
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